Bacterial resistance to silver: the role of SilE protein
نویسندگان
چکیده
منابع مشابه
SilE is an intrinsically disordered periplasmic “molecular sponge” involved in bacterial silver resistance
Ag(+) resistance was initially found on the Salmonella enetrica serovar Typhimurium multi-resistance plasmid pMG101 from burns patients in 1975. The putative model of Ag(+) resistance, encoded by the sil operon from pMG101, involves export of Ag(+) via an ATPase (SilP), an effluxer complex (SilCFBA) and a periplasmic chaperon of Ag(+) (SilE). SilE is predicted to be intrinsically disordered. We...
متن کاملModel peptide studies of Ag+ binding sites from the silver resistance protein SilE.
Using model peptides, each of the nine MX2H or HXnM (n = 1, 2) motifs of the silver resistance protein SilE has been shown to coordinate to one Ag+ ion by its histidine and methionine residues with Kd in the μM range. This suggests an Ag+ buffering role for SilE in the case of high Ag+ overload.
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15 صفحه اولAspects of Bacterial Resistance to Silver
Sütterlin, S. 2015. Aspects of Bacterial Resistance to Silver. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1084. 64 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9205-2. Bacterial resistance to antibiotics has increased rapidly within recent years, and it has become a serious threat to public health. Infections caused by multi-drug resist...
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Ionic silver exhibits antimicrobial activity against a broad range of micro-organisms. As a consequence, silver is included in many commercially available healthcare products. The use of silver is increasing rapidly in the field of wound care, and a wide variety of silver-containing dressings are now commonplace (e.g. Hydrofiber dressing, polyurethane foams and gauzes). However, concerns associ...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations and Advances
سال: 2016
ISSN: 2053-2733
DOI: 10.1107/s2053273316099204